The ASEAN Framework on Anticipatory Action in Disaster Management represents a significant shift in how the Association of Southeast Asian Nations (ASEAN) plans to tackle natural hazard-related disasters. The region is moving towards mechanisms for preparedness and response that can operate based on the One ASEAN One Response principles of speed, scale and solidarity. As climate change continues to increase the occurrence and intensity of extreme events, anticipatory action is fast becoming a critical approach in comprehensive disaster risk management. Rapid technological advances have allowed for early warning information to more accurate, readily available and better communicated than ever before. Meteorological agencies can increasingly predict extreme events that have the potential to result in significant economic and social losses. These gains come with the responsibility to act on warnings and ensure no one is left behind. Anticipatory action is an approach to translating warnings into action, in order to protect people and assets a hazard develops into a disaster. This Framework represents a landmark commitment from ASEAN to move the anticipatory action agenda forward in the sub-region. It supports ASEAN in achieving its long-term goals of securing a climate-resilient future – particularly as one of the most disaster-prone regions in the world. The Framework offers three critical directions. It provides guidance for defining anticipatory action for the region. This is a core aim of the document, particularly due to the proliferation of terms that have emerged around the approach over the years. Second, the framework contextualises the concept, offering three-building blocks to provide guidance and structure to national and regional anticipatory action efforts. Finally, it lays out an action plan that ASEAN Member States set through to 2025, and practical steps for policymakers and practitioners from the concerned sectors – social welfare, disaster risk management, agriculture and livelihoods, water and sanitation, among others – to work together in building the necessary foundations for leveraging anticipatory actions.